What is The Survival Rate of Spleen Cancer? Important Facts

The survival rate of spleen cancer largely depends on the stage at diagnosis, with early-stage malignancies having significantly better prognoses.

Spleen cancer is rare but can happen when cancer from another place moves to the spleen.1 It might start in the spleen directly, which is not usual.1 How well someone with spleen cancer does depends on when it’s found and its kind.1 Cancers caught early are often easier to treat than those found later.2 Since spleen cancers are not common, pinning down exact survival numbers can be hard. We’ll look at what affects how people do when they have spleen cancer.

Key Takeaways

  • Spleen cancer is an uncommon malignancy that can be primary or secondary (spread from another organ).
  • Survival rates for spleen cancer vary depending on the stage and specific type, with early-stage cancers generally having better prognoses.
  • Risk factors for spleen cancer include age, gender, immune system conditions, and exposure to certain infections and chemicals.
  • Treatment options for spleen cancer may include splenectomy, chemotherapy, radiation, and targeted therapies, depending on the individual case.
  • Preventive measures, such as healthy lifestyle choices and prompt treatment of infections, can help reduce the risk of spleen cancer.

Overview of Spleen Cancer

Primary spleen cancers are very rare. They make up a small part of all cancer cases.2 The most seen types are lymphomas and angiosarcomas.2

Splenic lymphomas like splenic marginal zone lymphoma and diffuse large B-cell lymphoma lead the chart.3 Primary splenic angiosarcoma, a dangerous vascular tumor, is also uncommon but bad.3 Knowing how rare and what types of spleen cancers exist is key. It helps do the right tests and treatments.

Rarity of Primary Spleen Cancers

Getting spleen cancer is not common. It usually comes from cancers moving to the spleen from elsewhere.2 Original spleen cancers are very rare. They are a small part of all cancer situations.2

Common Types: Lymphomas and Angiosarcomas

The most found spleen cancer types are lymphomas and angiosarcomas.2 Types like splenic marginal zone lymphoma and diffuse large B-cell lymphoma are often found.3 Primary angiosarcoma is a rare yet menacing type.3

Survival Rates for Splenic Lymphoma

Splenic lymphomas like splenic marginal zone lymphoma and diffuse large B-cell lymphoma have better survival chances than other spleen cancers. They see a 76.9% 5-year survival rate.3 This number changes based on the disease stage and type.

Factors Affecting Survival

If the lymphoma is in an advanced stage or it’s an aggressive type, the survival rate drops.3 It’s key to figure out both the stage and type to know how to best treat the disease. This step helps guess how long a patient might live.

Role of Staging and Histological Subtype

Disease stage and the type of lymphoma really matter. Early and local diseases offer better chances of surviving. But if it’s spread or it’s an aggressive type, survival might be harder.

splenic lymphoma

Splenic Marginal Zone Lymphoma Prognosis

Splenic marginal zone lymphoma (SMZL) is a slow-growing type of cancer in the spleen. It has a good outlook compared to other types of lymphoma.4 SMZL is the second most common type among those in groups with similar diseases. It makes up 20% of these cases.4 In the United States, people are usually 69 years old when they learn they have SMZL.4 Most people, about 83.4%, can expect to live five years or more after their diagnosis.4

The stage of the disease and certain genetic features affect how well someone might do. So does how well the first treatments work.5 If someone has an early-stage or low-risk SMZL, they often live a long time with the right treatments. These can include removing the spleen, giving chemotherapy, or using specific drugs.5

Diffuse Large B-Cell Lymphoma of the Spleen

Diffuse large B-cell lymphoma (DLBCL) is a tough cancer in the spleen. It makes up a big part of spleen cancers.3 People with this cancer might notice fast-growing lumps.

These lumps can be big and affect the spleen and nearby lymph nodes a lot.3 The chance of living 5 years is about 52.6%. This is lower than other spleen cancer kinds.

The cancer stage, how well the first treatment works, and certain gene signs all matter. They can change how well someone will do with this kind of cancer.

Treatment Outcomes and Survival

The way spleen cancer is treated really affects how long people live. Chemotherapy can help more with some types, like splenic lymphomas and primary splenic angiosarcoma. When chemo is part of the treatment, patients have a better chance at living through the cancer.32

Impact of Chemotherapy

Chemotherapy is key in treating spleen cancer. It’s especially good for fighting splenic lymphomas and the more rare but fast-growing primary splenic angiosarcoma. Using chemotherapy has shown to up the chances of surviving.32

Role of Splenectomy

Some spleen cancers need splenectomy, which is the removal of the spleen. But, it’s not always clear if this really helps people live longer. The need for splenectomy changes based on the spleen cancer type and how far it has spread. Doctors use many treatments together to get the best result for spleen cancer patients.32

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What is the Survival Rate of Spleen Cancer?

The survival rate for spleen cancer varies a lot. It depends on the type and stage of the cancer. For splenic lymphomas, the chance of living 5 years is about 76.9%.3 The rate for just this type of cancer is about 83.4%.3

But primary splenic angiosarcoma is very serious. It has a 5-year survival rate of only 11.8%. And most people survive for just 10 months after diagnosis.6 These big differences in rates show why early diagnosis and the right treatment are critical.

Primary Splenic Angiosarcoma

Primary splenic angiosarcoma is a rare but very fierce type of spleen cancer. It shows up with symptoms like belly pain, feeling tired, and having a fever.7 Finding it early is hard because these signs are common in many illnesses. Doctors often need to use pictures of the inside of the body and a small piece of tissue to be sure it’s this cancer.

Clinical Presentation and Diagnosis

People with this cancer often have big spleens, weighing over 1000 grams. Their belly area on the left side might feel big and hard.7 Feeling tired due to lack of red blood cells, called anemia, is very usual. And about 13% to 32% of the time, the spleen might burst.7

Extremely Poor Prognosis

Surviving this cancer is really tough, with only 11.8% making it to 5 years. The average time someone lives after finding out is just 10 months.7 This cancer grows fast and spreads quickly, making it hard to treat. We really need better ways to find it sooner and to treat it more effectively.

This cancer starts in the spleen’s special blood vessels or from special cells inside.7 Some tests that look at the cells suggest this might be where it comes from.7 It’s not clear if certain treatments or exposures can lead to getting this cancer.7

A lot of research has been done to understand this illness better.6 For example, in 1993, Falk and a team studied 40 cases.6 And in 2005, Thompson and others looked at images of 12 patients with this cancer.6 In 2000, Neuhauser and a group studied 28 cases to learn more about the cancer cells.6

Demographic and Racial Factors

The spleen cancer’s characteristics like age and race are important. They help us know the risks and understand this rare cancer. Spleen cancer, especially splenic lymphomas, is common in older people. The average age at diagnosis is around 65 years.8 Also, some groups, like African Americans, get this cancer more. They might not do as well as others.8 This may be because of genes, health before, and access to doctors. More study is needed to really see how these factors affect spleen cancer’s outlook.

Demographic FactorFindings
AgeSpleen cancer, especially splenic lymphomas, is seen more in older adults. The usual age at diagnosis is about 65 years.
RaceAfrican Americans, for example, seem to get spleen cancer more. And they may not do as well as other groups.

The differences between races in spleen cancer might be because of many things. Genes, past health, seeing doctors, and money could all play a part.8 We need to study more to understand what exactly causes these differences in how spleen cancer turns out.

Surveillance, Epidemiology, and End Results (SEER) Database Analysis

The SEER database helps us understand spleen cancer. It’s a big help in learning about the disease and how long people live after they get it. From the SEER data, we found that splenic lymphomas and primary splenic angiosarcoma are common types of spleen cancer.3 For splenic lymphomas, the chance of living 5 years is about 76.9%. But for primary splenic angiosarcoma, it’s only 11.8%. This tells us that spleen cancer is rare and can be different for each person. The SEER database really helps us know more about this disease.

Spleen Cancer Subtype5-Year Overall Survival Rate
Splenic Lymphomas76.9%3
Primary Splenic Angiosarcoma11.8%3

The SEER database is very important for spleen cancer research. It tells us a lot about the disease and how long people can live with it.3 We learned that splenic lymphomas and primary splenic angiosarcoma are the main types of spleen cancer. And we know that people with splenic lymphomas have a better chance of surviving for 5 years. The SEER database is key to understanding this rare cancer.

Challenges in Diagnosing Spleen Cancers

Finding spleen cancer can be hard. This is because it is rare, and the symptoms are not specific.9 Fewer cases of spleen cancer are seen than in other body parts.9 So, it makes it hard to find.

Imaging Modalities

CT scans, MRIs, and PET scans are used for looking at spleen cancer. They help doctors get a first look at possible cancer.9 CT scans are good for this. They tell more about the tumor, helping with further steps.9

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Biopsy Techniques

But, to be sure of spleen cancer, a biopsy is needed. This can be done in different ways.9 Doctors choose the best way to get a sample for testing. It is very important to choose the right method. This step is key in making sure the correct cancer type is found. It also helps plan the right treatment for spleen cancer patients.

Spleen Cancer Staging and Prognostic Factors

Spleen cancer staging tells us how to treat it and what to expect.10 The Ann Arbor system is common for finding cancer’s stage, especially in lymphomas. It uses numbers from 0 to IV based on how far the cancer has spread.10

The TNM system looks at the tumor, node, and metastasis. It gives a number for each category to show cancer’s spread.10

Different things can change how spleen cancer might turn out for someone. These include cancer’s stage at diagnosis, its type, genetic factors, and how it first responds to treatment.3

People with early stage cancers in just the spleen do better than those with cancer that has spread.3 Knowing these factors helps doctors plan the best care and give patients a clear idea of what to expect.

Prognostic FactorImpact on Spleen Cancer Survival
Stage of Disease at DiagnosisEarly-stage, localized spleen cancers generally have better survival outcomes compared to advanced-stage, metastatic disease.3
Histological SubtypeSplenic lymphomas, such as splenic marginal zone lymphoma, have more favorable prognoses compared to aggressive subtypes like primary splenic angiosarcoma.3
Genetic/Molecular AlterationsThe presence of certain genetic or molecular changes can impact the prognosis of spleen cancer patients.3
Response to Initial TreatmentPatients who respond well to initial treatment, such as chemotherapy or splenectomy, tend to have better survival outcomes.3

It’s key for doctors to know these factors for better planning.3 Good staging and look at these factors closely help in making the right treatment plan. This improves chances for those with this challenging cancer.

Treatment Strategies for Spleen Cancer

Spleen cancer treatment uses many approaches. It all depends on the cancer’s type and stage.3 Chemotherapy, like for lymphomas, has helped some types of spleen cancer patients live longer.11 Radiation therapy might also be used, alone or with other treatments.

Chemotherapy Regimens

Chemotherapy is a key part of spleen cancer therapy, especially for lymphomas.3 Doctors look at the type of spleen lymphoma to pick the best chemo.3 They’ve also studied dogs with spleen lymphoma who had their spleens removed. This helps know when chemo is best for them.

Radiation Therapy

Radiation therapy is used at times, alone or with other treatments.3 Studies have looked at how to use scans to check if radiation therapy is working. This includes looking at primary spleen lymphoma cases.

Splenectomy and Surgery

Removing the spleen, called a splenectomy, was once the main treatment. It often helped patients go a long time without the cancer coming back.11 But, we’re not sure how much this surgery helps everyone. The decision for surgery changes with the spleen cancer’s type and stage.3 Doctors have also learned from treating dogs with spleen lymphoma. This shows surgery can be important in some cases.

A team of different doctors looking at a patient’s case together is key. They decide the best treatment based on the cancer type, the patient’s health, and what each treatment can do good and bad.

Supportive Care and Quality of Life

Dealing with spleen cancer is tough. But, care and focus on life’s quality matter as much as the treatment itself. Those with spleen cancer feel symptoms from the disease or treatment. This can hit their body and mind hard. Supportive care like easing pain, helping with food, and handling side effects is crucial. It makes life better for the patient.2 It’s also key to have emotional support, special care, and help for survivors and their families.

Ongoing Research and Clinical Trials

Spleen cancer is rare. But research and trials are important for learning more and helping patients.3 Scientists look into new things about spleen cancer. They try to find unique signs for early detection. They also work on making treatments that target the disease better. And they try to mix different treatments to see what works best.

Clinical trials test new medicines and ways to fight cancer. They check how well these treatments work and if they’re safe.12 All this work means patients might have better chances of beating spleen cancer. By getting to know more about these types of cancer, we can also try to help more people live longer.


Spleen cancer is very rare and hard to deal with. It has its own way of needing attention when it comes to finding it, treating it, and fighting it off. The survival rate for spleen cancer changes a lot. It mostly depends on what kind it is and how far it has spread.3 Some types, like splenic marginal zone lymphoma and diffuse large B-cell lymphoma, are often easier to fight than primary splenic angiosarcoma, which is very tough.7

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How bad the cancer is, what kind it is, and how it responds to treatment can change the chances of living longer or beating it.10 It is very important that doctors and scientists keep learning more and trying new ways to treat spleen cancer. This can help to make things better for people fighting this tricky cancer. Healthcare teams need to work together. They do this to look for the right signs, use the best tests, and make plans that are just for the person, to give the best care.

Even though the idea of spleen cancer conclusion and what it means might sound scary, we should keep hopeful. The hard work of doctors, scientists, and new discoveries are offering hope. They might make the future brighter for those battling this not-so-common type of cancer.


What is the survival rate for spleen cancer?

The survival rate for spleen cancer varies a lot. It depends on the type and stage of cancer. For example, splenic lymphomas have a 5-year survival rate of around 76.9%. But, primary splenic angiosarcoma has a much lower rate of only 11.8%.

What are the common types of spleen cancer?

The most common types are spleen lymphomas. This includes splenic marginal zone lymphoma and diffuse large B-cell lymphoma. Also, there’s primary splenic angiosarcoma. It is a rare and very aggressive tumor.

What factors affect the survival rate for splenic lymphomas?

Several things can affect the chances of recovery from splenic lymphomas. These include the cancer’s stage at diagnosis and its exact type. The presence of certain genetic changes is also important. Plus, how well the initial treatment works.

What is the prognosis for splenic marginal zone lymphoma (SMZL)?

SMZL has a pretty good prognosis, with a 5-year survival rate as high as 83.4%. The chances of survival are affected by the disease’s stage and treatment response. Genetics also play a role.

How does the prognosis differ for diffuse large B-cell lymphoma (DLBCL) of the spleen?

DLBCL of the spleen is more aggressive. Its 5-year survival rate is around 52.6%. This is lower than other types of splenic lymphomas.

How does treatment impact the survival outcomes for spleen cancer?

Treatment can greatly affect the chances of survival. Chemotherapy can help certain types of spleen cancer. But, the impact of spleen removal (splenectomy) on survival is not clear. This depends on the cancer’s type and stage.

What is the survival rate for primary splenic angiosarcoma?

Primary splenic angiosarcoma is highly aggressive. It has a very low 5-year survival rate of 11.8%. The median overall survival is just 10 months.

Are there any demographic or racial factors that influence spleen cancer survival?

Spleen cancer, especially splenic lymphomas, is more common in older people. The average age at diagnosis is about 65 years. Some racial differences exist. For example, African Americans might have a higher chance of getting spleen cancer and a lower survival rate.

How does the SEER database contribute to our understanding of spleen cancer?

The SEER database gives us important information about spleen cancer. It shows that splenic lymphomas and primary splenic angiosarcoma are the most common types. The 5-year survival rates are about 76.9% for splenic lymphomas and 11.8% for angiosarcoma.

What are the challenges in diagnosing spleen cancer?

Diagnosing spleen cancer is hard because symptoms are rare and vague. Doctors use imaging tests like CT and PET scans to start. But, a biopsy is needed for a definite diagnosis.

What is the role of staging and prognostic factors in spleen cancer?

Staging is key in deciding how to treat spleen cancer and in predicting the outlook. The cancer’s stage, its specific type, genetic changes, and treatment response all affect the outcome.

What are the treatment strategies for spleen cancer?

Spleen cancer is treated with chemo, radiation, and sometimes surgery to remove the spleen. The treatment plan is based on cancer type, stage, and the patient’s health and choices.

How does supportive care and quality of life play a role in spleen cancer management?

Supportive care is crucial alongside cancer treatment. This includes managing pain, helping with nutrition, and offering emotional support. It improves the patient’s quality of life.

What are the ongoing research and clinical trials for spleen cancer?

Research and clinical trials continue to find better ways to treat spleen cancer. Scientists are looking at new biomarkers, targeted therapies, and how best to combine treatments to help patients. The goal is to make treatments more effective and easier for the patient.

Source Links

  1. https://www.healthline.com/health/spleen-cancer
  2. https://www.baptisthealth.com/care-services/conditions-treatments/spleen-cancer
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772628/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056760/
  5. https://lymphoma-action.org.uk/types-lymphoma-non-hodgkin-lymphoma/splenic-marginal-zone-lymphoma
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822683/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041046/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8553578/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614769/
  10. https://cansa.org.za/files/2021/10/Fact-Sheet-on-Cancer-of-the-Spleen-NCR-2017-web-October-2021.pdf
  11. https://www.medicalnewstoday.com/articles/321951
  12. https://pubmed.ncbi.nlm.nih.gov/35060511/